The problem many children especially girls have school is getting more and more serious.

问题补充：

The problem many children,especially girls,have school is getting more and more serious.

A. which;got out of

B. that;dropped out of

C. that;fallen out of

D. which;run out of

答案：

A. which;got out of

(答案→)B. that;dropped out of

C. that;fallen out of

D. which;run out of

解析：第一空需要引导同位语从句的词，而which不可引导同位语从句。故排除A、D两项。drop out of school意为“辍学”，故选B项。